Guidelines for inflammation models in mice for food components

Inflammation is one of the major health threats to humans, and it associated with various chronic diseases, including metabolic syndrome, type 2 diabetes, cardiovascular several types cancer. For example, colonic inflammation can result in damage intestinal barrier, as indicated by invasion immune cells reduced tight junctions. Inflammatory responses also lead erythema edema on skin. The intervention dietary components offers striking possibilities for prevention modulating inflammatory signaling pathways microbiota–inflammation axis. Thus, preclinical animal models are critical importance investigating anti-inflammatory effects food components. This guideline introduces two mouse models: dextran sulfate sodium-induced 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation. These mimic offer potential assess attenuating humans.